Research suggests new avenue for stopping, preventing colon cancer
Researchers at the Vanderbilt-Ingram Cancer Center (VICC) have provided the first evidence that blocking a cellular receptor can inhibit the development of ...
http://www.eurekalert.org/pub_releases/2004-09/vumc-rsn091504.php - size 8.3K

Vioxx in high doses causes hypertension
Despite previous warnings, a substantial number of people continue to be prescribed high doses of Cox-2 inhibitors, rising risks of heart problems.
http://www.eurekalert.org/pub_releases/2004-07/vumc-vih071304.php - size 8.4K

Stat3 controls inflammation, reducing tissue damage in rats after acute lung injury
U-M scientists have discovered that Stat3, an anti-inflammatory protein, appears to regulate the inflammatory response in lab rats with severe lung ...
http://www.eurekalert.org/pub_releases/2004-06/uomh-sci062104.php - size 8.2K

New non-aspirin pain drug proves effective against recurrent prostate cancer
Early results from a University of North Carolina at Chapel Hill School of Medicine study may determine if drugs called Cox-2 inhibitors, a newer type of ...
http://www.eurekalert.org/pub_releases/2004-06/uonc-nnp060904.php - size 8.9K

Discovery changes ideas about damage from strokes
Scientists hunting for culprits that lead to brain damage after strokes have discovered that one likely "bad guy" is actually a "good guy."
http://www.eurekalert.org/pub_releases/2004-01/jhmi-dci011204.php - size 7.1K

For those who take painkillers regularly, a heartburn pill a day may keep ulcers away
For those who take certain painkiller drugs regularly to help ease arthritis pain or other chronic aches, the relief comes with a tradeoff: a quadrupled chance of ...
http://www.eurekalert.org/pub_releases/2003-10/uomh-ftw101003.php - size 7.9K

Use of common anti-inflammatory drug fails to slow progression of Alzheimer's disease
Hopes that Aleve and Vioxx, two common nonsteroidal anti-inflammatory drugs, could slow the progression of Alzheimer's disease have been dashed as researchers ...
http://www.eurekalert.org/pub_releases/2003-06/gumc-uoc060203.php - size 7.0K

UCLA researchers study popular arthritis drugs
A new UCLA and Veterans Affairs Greater Los Angeles Healthcare System study demonstrates that a popular class of arthritis drugs is not as cost-effective as common painkillers in ...
http://www.eurekalert.org/pub_releases/2003-05/uoc--urs051903.php - size 6.9K

Colonoscopy far more cost-effective against colon cancer than promising Cox II drugs, study ...
A new study gives Americans over 50 one more reason not to put off having a colonoscopy to check for colon cancer and its forerunners. Not only is ...
http://www.eurekalert.org/pub_releases/2003-05/uomh-cfm050103.php - size 12.5K

COX-2 enzyme instrumental in Parkinson's disease
Research by neurologists at Columbia University suggests that COX-2 inhibitors like Celebrex and Vioxx may someday help Parkinson's disease patients by preventing the death of neurons that ...
http://www.eurekalert.org/pub_releases/2003-04/cuco-cei040703.php - size 5.8K

Daily aspirin lowers colorectal cancer risk
A daily aspirin can prevent polyps in patients at high risk for colorectal cancer, according to a new study. Aspirin reduced the ocurrence of polyps by one-third. Patients on aspirin who ...
http://www.eurekalert.org/pub_releases/2003-03/uocm-dal022803.php - size 9.6K

California chemist wins national award for drug discoveries
Paul J. Reider of Thousand Oaks, Calif., will be honored March 25 by the American Chemical Society for his pivotal role in the development of new therapies for AIDS, asthma and ...
http://www.eurekalert.org/pub_releases/2003-03/acs-ccw030403.php - size 5.2K

Researchers show COX-2 inhibitors interfere with bone growth, healing
Researchers at Stanford University Medical Center have found that selective COX-2 inhibitors - a class of medications widely prescribed for painful inflammatory ...
http://www.eurekalert.org/pub_releases/2002-11/sumc-rsc111902.php - size 7.8K

COX-2 inhibitors and the elderly
In their study of drug claims data, Muhammad Mamdani and colleagues report most of the patients among initial users of COX-2 inhibitors did not have a prescription claim for another ...
http://www.eurekalert.org/pub_releases/2002-11/cmaj-cia110802.php - size 4.1K

Zebrafish: Drug discovery of a different stripe holds promise in COX research
University of Pennsylvania researchers have discovered that zebrafish produce enzymes analogous to the two human cyclooxygenase (COX) enzymes – COX-1 and –2 – ...
http://www.eurekalert.org/pub_releases/2002-06/uopm-zdd061302.php - size 8.5K

Choose your painkillers with care
Some painkillers may delay or even completely prevent the healing of fractures. American researchers say that when they gave non-steroidal anti-inflammatory drugs to rats their broken bones ...
http://www.eurekalert.org/pub_releases/2002-06/ns-cyp060502.php - size 6.1K

Jefferson scientists find Cox-2 may play role in some brain tumors
Oncologists have shown for the first time that the enzyme cyclooxygenase-2 (COX-2), which is the target for the anti-arthritis drugs - and COX-2 inhibitors - ...
http://www.eurekalert.org/pub_releases/2002-05/tju-jsf051702.php - size 6.3K

Solving the COX conundrum
Cyclooxygenase (COX) is a pharmacologically important enzyme that has a role in blood clotting and inflammation. The relationship between its two major forms and their products, however, has been ...
http://www.eurekalert.org/pub_releases/2002-04/uopm-stc041202.php - size 7.6K

Ibuprofen blocks aspirin’s ability to protect against heart attacks
The ibuprofen that you take to ease arthritis pain can counteract the aspirin that you take to protect your heart. The researchers were looking to see how aspirin, taken to ...
http://www.eurekalert.org/pub_releases/2001-12/uopm-iba121801.php - size 8.2K

Non-aspirin pain drug may slow ligament healing
A new class of non-aspirin pain medicine now widely prescribed for arthritis symptoms may impair ligament healing associated with sprains, according to laboratory findings at the ...
http://www.eurekalert.org/pub_releases/2001-11/uonc-npd111501.php - size 6.2K

Mice with human protein, COX-2, exhibit age-related memory loss similar to Alzheimer's disease
A new player is emerging in the complex world of the brain. This player, a protein called COX-2, appears to be critically important in the brain's ...
http://www.eurekalert.org/pub_releases/2001-11/jhmi-mwh111201.php - size 9.6K

Popular arthritis drug may enhance radiation effects against cancer
Researchers at Jefferson Medical College have shown in the laboratory that a popular arthritis drug may enhance the effects of radiation against tumor cells. Using ...
http://www.eurekalert.org/pub_releases/2001-11/tju-pad110601.php - size 5.7K

Blood vessels found to signal chain of destruction in bone diseases
Biologists at Washington University in St. Louis have discovered a mechanism in blood vessels that opens the door for bone loss in such diseases as rheumatoid arthritis, ...
http://www.eurekalert.org/pub_releases/2001-06/aaft-bvf062601.php - size 9.4K

Prescription drug use patterns complicated by wide regional variation
California and New York may be the nation’s most populous states, but they and other big states like Florida, New Jersey, Minnesota, and Massachusetts, placed at or ...
http://www.eurekalert.org/pub_releases/2001-06/KPC-Pdup-1806101.php - size 21.1K

Aspirin and other non-specific COX inhibitors may slow atherosclerosis
Mouse-model research by scientists at the University of Pennsylvania School of Medicine has demonstrated that aspirin, ibuprofen and other drugs in the class of ...
http://www.eurekalert.org/pub_releases/2001-03/UoPM-Aaon-0603101.php - size 7.2K

Procter & Gamble donates proprietary "super aspirin" technology to Vanderbilt University
Procter & Gamble donated a collection of 196 patents and pending patents for "COX-2 Inhibitor Technology" to Vanderbilt University. The collection of COX-2 ...
http://www.eurekalert.org/pub_releases/2000-11/VUMC-PGdp-0111100.php - size 8.9K

Express Scripts 1999 drug trend report: Seniors hit hardest by record 17.4-Percent ...
Spending on prescription drugs increased a record 17.4 percent last year, with senior citizens 70 years or older seeing the biggest cost increases ...
http://www.eurekalert.org/pub_releases/2000-06/KPC-ES1d-2606100.php - size 11.4K

New pain reliever for rheumatoid arthritis works with fewer gastrointestinal side effects
A new kind of arthritis drug provides the same relief of pain and inflammation in people with rheumatoid arthritis as a typical nonsteroidal ...
http://www.eurekalert.org/pub_releases/1999-11/BIDM-Nprf-221199.php - size 7.9K

New Anti-Inflammatory Drug Is Easy On The Stomach
A large-scale (1500-patient) test of rofecoxib, an example of a new family of non-steroidal anti-inflammatory drugs, indicates that the new pharmaceutical causes significantly ...
http://www.eurekalert.org/pub_releases/1999-05/UoSC-NADI-170599.php - size 5.5K

How Super Are The "Super Aspirins"? -- New COX-2 Inhibitors May Elevate Cardiovascular Risk
The so-called "super aspirins," or COX-2 inhibitors, may have a downside, one that could not have been detected in the clinical trials performed to ...
http://www.eurekalert.org/pub_releases/1999-01/UoPM-HSAT-140199.php - size 9.1K

Physicians Study Whether "Super-Aspirin" Prevents Alzheimer's
Doctors at the University of Rochester and 39 other medical centers around the nation have begun a research study to see if a drug known as a super-aspirin -- an investigational ...
http://www.eurekalert.org/pub_releases/1998-11/UoR-PSWP-191198.php - size 6.0K